Synthesis and biological evaluation of cytogenin derivatives

  • J Antibiot (Tokyo). 2001 Mar;54(3):285-96. doi: 10.7164/antibiotics.54.285.
N Matsumoto  1 ,  T Nakashima ,  K Isshiki ,  H Kuboki ,  S I Hirano ,  H Kumagai ,  T Yoshioka ,  M Ishizuka ,  T Takeuchi
Affiliations
  • 1. Central Research Laboratories, Mercian Corp, Johnan, Fujisawa, Japan. [email protected]
PMID: 11372785 DOI: 10.7164/antibiotics.54.285
Abstract

To enhance the stability in vivo, new derivatives of cytogenin were synthesized, and their biological activity and stability in mice were estimated. 2-(8-Hydroxy-6-methoxy-1-oxo-1H-2-benzopyran-3-yl)propionic acid (NM-3) was found to be the most stable among them. It modified collagen-induced arthritis in mice. It also showed potent anti-angiogenic activity in a mouse dorsal air sac assay.

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