Thiazole analogues of the NSAID indomethacin as selective COX-2 inhibitors
- Bioorg Med Chem Lett. 2001 May 21;11(10):1325-8. doi: 10.1016/s0960-894x(01)00212-8.
Affiliations
- 1. Abbott Laboratories, Abbott Park, IL 60064-6101, USA. [email protected]
PMID: 11392547
DOI: 10.1016/s0960-894x(01)00212-8
Abstract
The carboxyl group of the NSAID indomethacin was replaced with a variety of substituted thiazoles to obtain a series of potent, selective inhibitors of COX-2. Additional substitutions were made at the 1-position and 5-position of the indole of indomethacin.