Two new cytotoxic and virucidal trisulfated triterpene glycosides from the Antarctic sea cucumber Staurocucumis liouvillei

  • J Nat Prod. 2001 Jun;64(6):732-6. doi: 10.1021/np000584i.
M S Maier  1 ,  A J Roccatagliata ,  A Kuriss ,  H Chludil ,  A M Seldes ,  C A Pujol ,  E B Damonte
Affiliations
  • 1. Departamento de Química Orgánica, Facultad de Ciencias Exactas y Naturales, Pabellón 2, Ciudad Universitaria, 1428 Buenos Aires, Argentina. [email protected]
PMID: 11421733 DOI: 10.1021/np000584i
Abstract

Two new trisulfated triterpene glycosides, liouvillosides A (1) and B (2), have been isolated from the Antarctic sea cucumber Staurocucumis liouvillei. Their structures have been elucidated by spectroscopic analysis (NMR and FABMS) and chemical transformations. Liouvillosides A (1) and B (2) are two new examples of a small number of trisulfated triterpene glycosides from sea cucumbers belonging to the family Cucumariidae. Both glycosides were found to be virucidal against herpes simplex virus type 1 (HSV-1) at concentrations below 10 microg/mL.

Products