N,N-dibenzyl-N'-benzylidenehydrazines: potent competitive glucose-6-phosphatase catalytic enzyme inhibitors

  • Bioorg Med Chem Lett. 2001 Aug 20;11(16):2165-7. doi: 10.1016/s0960-894x(01)00395-x.
P Madsen  1 ,  P Jakobsen ,  N Westergaard
Affiliations
  • 1. Medicinal Chemistry Research, Novo Nordisk A/S, Novo Nordisk Discovery, Novo Nordisk Park, DK-2760, Maaloev, Denmark. [email protected]
PMID: 11514161 DOI: 10.1016/s0960-894x(01)00395-x
Abstract

A novel class of N,N-dibenzyl-N'-benzylidenehydrazines as potent and competitive glucose-6-phosphatase catalytic site inhibitors are described. Optimisation of this series identified compounds with IC(50) values as low as 170 nM.

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