Antidepressant activity of aspartic acid derivatives

  • Bull Exp Biol Med. 2001 Apr;131(4):342-5. doi: 10.1023/a:1017948001979.
V I Petrov  1 ,  V S Sergeev ,  N V Onishchenko ,  L B Piotrovskii
Affiliations
  • 1. Laboratory of Psychopharmacology, Institute of Pharmacology, Volgograd Medical Academy, St.-Petersburg.
PMID: 11550022 DOI: 10.1023/a:1017948001979
Abstract

Antidepressant activity of N-phenyl(benzyl)amino derivatives of aspartic acid was studied on various experimental models of depression. IEM-1770 (30 mg/kg) and IEM-1944 (20 mg/kg) exhibited antidepressant activity after single injection in the forced swimming and tail suspension tests. Antidepressant effect of 14-day administration of these compounds and reference drugs maprotiline (10 mg/kg) and citalopram (10 mg/kg) was confirmed on the model of learned helplessness.

Products