New cytotoxic sesterterpenes from the sponge Sarcotragus species

  • J Nat Prod. 2001 Oct;64(10):1301-4. doi: 10.1021/np0101494.
Y Liu  1 ,  B H Bae ,  N Alam ,  J Hong ,  C J Sim ,  C O Lee ,  K S Im ,  J H Jung
Affiliations
  • 1. College of Pharmacy, Pusan National University, Pusan 609-735, Korea.
PMID: 11678655 DOI: 10.1021/np0101494
Abstract

Five new (1-3, 5, and 7) and two known (4, 6) furanosesterterpene tetronic acids were isolated from the marine Sponge Sarcotragus sp. by bioactivity-guided fractionation. These compounds showed cytotoxicity against a panel of five human tumor cell lines. The gross structures were established on the basis of NMR and MS analyses. The compounds showed interesting variations of geometry and absolute configuration.