Pyloricidins, novel anti-helicobacterpylori antibiotics produced by Bacillus sp. I. Taxonomy, fermentation and biological activity

  • J Antibiot (Tokyo). 2001 Nov;54(11):926-33. doi: 10.7164/antibiotics.54.926.
M Nakao  1 ,  K Miyagaw ,  Y Nakano ,  T Sakane ,  M Tada ,  O Nishimura ,  M Fujino
Affiliations
  • 1. Pharmacology Research laboratories II, Pharmaceutical Research Division, Takeda Chemical Industries, Ltd., Osaka, Japan.
PMID: 11827035 DOI: 10.7164/antibiotics.54.926
Abstract

Novel anti-Helicobacter pylori Antibiotics, pyloricidins A, A1, A2, B, C and D, were discovered in the culture broth of two bacilli strains. Pyloricidins selectively inhibited the growth of H. pylori. Pyloricidin B was efficacious in the treatment of gastric Infection caused by H. pylori in Mongolian gerbils and may be promising for cure of H. pylori Infection as a single agent.

Products