Cephalocyclidin A, a novel pentacyclic alkaloid from Cephalotaxus harringtonia var. nana

  • J Org Chem. 2002 Apr 5;67(7):2283-6. doi: 10.1021/jo016327f.
Jun'ichi Kobayashi  1 ,  Miwa Yoshinaga ,  Naotoshi Yoshida ,  Motoo Shiro ,  Hiroshi Morita
Affiliations
  • 1. Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan. [email protected]
PMID: 11925242 DOI: 10.1021/jo016327f
Abstract

A novel alkaloid with an unprecedented fused-pentacyclic skeleton and six-consecutive asymmetric centers, cephalocyclidin A (1), has been isolated from the fruits of Cephalotaxus harringtonia var. nana, and the structure was elucidated on the basis of spectroscopic data. The relative and absolute stereochemistry of 1 was determined by a combination of NOESY correlations, X-ray crystallographic data, and the exciton chirality method.

Products