Synthesis of novel furo, thieno, and benzazetoazepines and evaluation of their cytotoxicity

  • Bioorg Med Chem Lett. 2002 Jun 17;12(12):1675-7. doi: 10.1016/s0960-894x(02)00232-9.
L Roberto Martínez  1 ,  Jose Gustavo Avila Zarraga ,  Ma Esther Duran ,  Ma Teresa Ramírez Apam ,  Roberto Cañas
Affiliations
  • 1. Instituto de Química, Universidad Nacional Autónoma de México, Circuito Exterior, Ciudad Universitaria, 04510 Coyoacán, México, D.F., Mexico. [email protected]
PMID: 12039588 DOI: 10.1016/s0960-894x(02)00232-9
Abstract

We report the regio- and stereoselective synthesis of a novel cis-C(3)N-C(4)X-C(6)N series (X=O, S, and C(2)) from cyclic ketones. The cytotoxic activity of the new compounds was studied in five cell lines; the observed activities were in accordance with the concept of bioisosteric replacement.