Agonodepsides a and B: two new depsides from a filamentous fungus F7524

  • J Nat Prod. 2002 Jul;65(7):1037-8. doi: 10.1021/np010626i.
Shugeng Cao  1 ,  Alex S Y Lee ,  Yicun Huang ,  Horst Flotow ,  Siewbee Ng ,  Mark S Butler ,  Antony D Buss
Affiliations
  • 1. Centre for Natural Product Research, Institute of Molecular and Cell Biology, 59A Science Park Drive, The Fleming, Singapore Science Park 118240, Singapore. [email protected]
PMID: 12141869 DOI: 10.1021/np010626i
Abstract

Two new compounds, agonodepsides A (1) and B (2), were isolated from a nonsporulating filamentous fungus, F7524. The compounds were purified via reversed-phase chromatography and their structures determined by spectroscopic methods. Agonodepside A (1) was found to inhibit the mycobacterial InhA enzyme with an IC50 value of 75 microM, while 2 was inactive at 100 microM.

Products