Atropisomeric myristinins: selective COX-2 inhibitors and antifungal agents from Myristica cinnamomea

  • J Org Chem. 2002 Aug 9;67(16):5470-5. doi: 10.1021/jo020045d.
Supaporn Sawadjoon  1 ,  Prasat Kittakoop ,  Kanyawim Kirtikara ,  Vanicha Vichai ,  Morakot Tanticharoen ,  Yodhathai Thebtaranonth
Affiliations
  • 1. Department of Chemistry, Faculty of Science, Mahidol University, Bangkok 10400, Thailand.
PMID: 12153244 DOI: 10.1021/jo020045d
Abstract

The first naturally occurring atropisomeric flavans, myristinins B (2), C (2a), E (4), and F (4a), together with their corresponding trans-isomers, myristinins A (1) and D (3), were isolated from the CH(2)Cl(2) extract of Myristica cinnamomea fruits. Compounds 1, the mixture of 2 and 2a, and the mixture of 4 and 4a, exhibited Antifungal activity against Candida albicans with IC(50) values ranging from 5.9 to 8.8 microg/mL, and they selectively inhibited the enzyme cyclooxygenase-2 (COX-2).

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