Binding selectivity of conformationally restricted analogues of (-)-indolactam-V to the C1 domains of protein kinase C isozymes

  • Biosci Biotechnol Biochem. 2002 Jul;66(7):1615-7. doi: 10.1271/bbb.66.1615.
Akiko Masuda  1 ,  Kazuhiro Irie ,  Yu Nakagawa ,  Hajime Ohigashi
Affiliations
  • 1. Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Japan.
PMID: 12224655 DOI: 10.1271/bbb.66.1615
Abstract

Two conformationally restricted analogues of (-)-indolactam-V (1) (cis and trans amides) were examined for their binding selectivity to the synthetic C1 peptides of all protein kinase C (PKC) isozymes. Although the binding constants of the cis amide-restricted analogue (2) were equal to those of 1, the trans amide-restricted analogue (3) bound significantly only to the novel PKC (delta, epsilon, eta, theta) isozymes.

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