Interiotherins C and D, two new lignans from Kadsura interior and antitumor-promoting effects of related neolignans on Epstein-Barr virus activation

  • J Nat Prod. 2002 Sep;65(9):1242-5. doi: 10.1021/np0105127.
Dao-Feng Chen  1 ,  Shun-Xiang Zhang ,  Mutsuo Kozuka ,  Quan-Zhong Sun ,  Ju Feng ,  Qiang Wang ,  Teruo Mukainaka ,  Yoshitaka Nobukuni ,  Harukuni Tokuda ,  Hoyoku Nishino ,  Hui-Kang Wang ,  Susan L Morris-Natschke ,  Kuo-Hsiung Lee
Affiliations
  • 1. Department of Pharmacognosy, School of Pharmacy, Fudan University, Shanghai 200032, People's Republic of China.
PMID: 12350139 DOI: 10.1021/np0105127
Abstract

Two new Lignans, interiotherins C (1) and D (2), together with the known compounds interiorin (3), heteroclitin F (4), neokadsuranin (5), heteroclitin D (6), kadsurin (7), gomisin A (8), schisandrin C (9), interiotherin A (10), angeloylgomisin R (11), gomisin G (12), interiotherin B (13), and gomisin C (14), were isolated from the stems of Kadsura interior. The structures and stereochemistries of the new compounds were determined from mass, CD, and NMR spectral data. Fourteen neolignans were screened as potential antitumor promoters by examining their ability to inhibit Epstein-Barr virus early antigen (EBV-EA) activation (induced by 12-O-tetradecanoylphorbol-13-acetate) in Raji cells. Neokadsuranin (5) and schisandrin C (9) were the most potent compounds. These data suggest that some neolignans might be valuable antitumor promoters or chemopreventors.

Products