New acetylenic acids from the marine sponge Stelletta species

  • J Nat Prod. 2003 Mar;66(3):408-11. doi: 10.1021/np020440z.
Qingchun Zhao  1 ,  Seung-Yeon Lee ,  Jongki Hong ,  Chong-O Lee ,  Kwang Sik Im ,  Chung Ja Sim ,  Dong Seok Lee ,  Jee H Jung
Affiliations
  • 1. College of Pharmacy, Pusan National University, Busan 609-735, Korea, Korea.
PMID: 12662102 DOI: 10.1021/np020440z
Abstract

Four new acetylenic acids were isolated from the marine Sponge Stelletta sp. by bioactivity-guided fractionation. The planar structures were established on the basis of NMR and MS analysis. The stereochemistry was defined by combined use of CD spectroscopy and a chiral anisotropic reagent, phenylglycine methyl ester (PGME). The compounds were evaluated for cytotoxicity against a small panel of five human tumor cell lines and exhibited marginal to moderate cytotoxicity.