Human herpesvirus 6 variant A glycoprotein H-glycoprotein L-glycoprotein Q complex associates with human CD46

  • J Virol. 2003 Apr;77(8):4992-9. doi: 10.1128/jvi.77.8.4992-4999.2003.
Yasuko Mori  1 ,  Xuwei Yang ,  Pilailuk Akkapaiboon ,  Toshiomi Okuno ,  Koichi Yamanishi
Affiliations
  • 1. Department of Microbiology, Osaka University Medical School, Suita, Osaka 565-0871, USA. [email protected]
PMID: 12663806 DOI: 10.1128/jvi.77.8.4992-4999.2003
Abstract

Human CD46 is a cellular receptor for human herpesvirus 6 (HHV-6). Virus entry into host cells requires a glycoprotein H (gH)-glycoprotein L (gL) complex. We show that the CD46 ectodomain blocked HHV-6 Infection and bound a complex of gH-gL and the 80-kDa U100 gene product, designated glycoprotein Q, indicating that the complex is a viral ligand for CD46.