Beta A4 amyloid protein and its precursor in Alzheimer's disease

  • Pharmacol Ther. 1992;56(1):97-117. doi: 10.1016/0163-7258(92)90039-3.
A I Bush  1 ,  K Beyreuther ,  C L Masters
Affiliations
  • 1. Department of Pathology, University of Melbourne, Parkville, Australia.
PMID: 1297146 DOI: 10.1016/0163-7258(92)90039-3
Abstract

The beta A4 amyloid protein is now understood to play a pivotal role in the development of Alzheimer's disease. This protein is generated by the abnormal processing of the amyloid protein precursor, a large membrane glycoprotein. Insights into the mechanisms of this abnormal processing will give information relevant to the design of new therapeutic strategies for Alzheimer's disease.