Lacidipine: a dihydropyridine calcium antagonist with antioxidant activity

  • Free Radic Biol Med. 1992;12(3):183-7. doi: 10.1016/0891-5849(92)90025-c.
F T van Amsterdam  1 ,  A Roveri ,  M Maiorino ,  E Ratti ,  F Ursini
Affiliations
  • 1. Glaxo Research Laboratories, Verona, Italy.
PMID: 1314212 DOI: 10.1016/0891-5849(92)90025-c
Abstract

Lacidipine, a new, long-acting antihypertensive dihydropyridine calcium antagonist was tested for potential antioxidant effect in a series of tests that consider specific radical species. A direct quenching of several radical species could be measured. Moreover, in biological membranes deriving from rat brain tissue, lacidipine showed an activity comparable to reference antioxidant compounds like vitamin E.

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