A novel cytotoxic guttiferone analogue from Garcinia macrophylla from the Suriname rainforest

  • Planta Med. 2003 Sep;69(9):864-6. doi: 10.1055/s-2003-43204.
Russell B Williams  1 ,  Jeannine Hoch ,  Thomas E Glass ,  Randy Evans ,  James S Miller ,  Jan H Wisse ,  David G Kingston
Affiliations
  • 1. Department of Chemistry M/C 0212, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA.
PMID: 14598218 DOI: 10.1055/s-2003-43204
Abstract

Bioassay-guided fractionation of the EtOAc extract of the twigs of Garcinia macrophylla from Suriname produced the known benzophenone, guttiferone A (1), and a new guttiferone analogue, guttiferone G (2). Friedelin was also isolated. The structures of compounds 1 and 2 were elucidated using 1D and 2D NMR spectroscopy. Compounds 1 and 2 were weakly cytotoxic in the A2780 human ovarian cell line, with IC (50) values of 6.8 and 8.0 microg/mL, respectively.

Products