New cytotoxic sesterterpenoids and norsesterterpenoids from two sponges of the genus Sarcotragus

  • J Nat Prod. 2003 Nov;66(11):1451-6. doi: 10.1021/np030268e.
Yonghong Liu  1 ,  Tayyab A Mansoor ,  Jongki Hong ,  Chong-O Lee ,  Chung Ja Sim ,  Kwang Sik Im ,  Nam Deuk Kim ,  Jee H Jung
Affiliations
  • 1. College of Pharmacy, Pusan National University, Busan 609-735, Korea.
PMID: 14640517 DOI: 10.1021/np030268e
Abstract

New norsesterterpenoids (3 and 4), a sesterterpenoid (6), pyrroloterpenoids (7-10), and a stereoisomer of kurospongin (5) were isolated, along with known furanosesterterpenes (11-15), from two marine sponges of the genus Sarcotragus. The gross structures were established on the basis of NMR and MS analysis. The stereochemistry was defined by combined use of NMR and CD spectroscopy. The compounds were evaluated for cytotoxicity against five human tumor cell lines and were found to exhibit marginal to moderate activity.