Doxorubicin prodrug on the basis of tert-butyl cephalosporanate sulfones

  • Bioorg Med Chem Lett. 2004 Feb 23;14(4):1007-10. doi: 10.1016/j.bmcl.2003.11.071.
Grigory Veinberg  1 ,  Irina Shestakova ,  Maxim Vorona ,  Iveta Kanepe ,  Ilona Domrachova ,  Edmunds Lukevics
Affiliations
  • 1. Latvian Institute of Organic Synthesis, 21 Aizkraukles Street, Riga, LV 1006, Latvia. [email protected]
PMID: 15013011 DOI: 10.1016/j.bmcl.2003.11.071
Abstract

Doxorubicin-cephalosporin prodrug adapted to the development of elastases for the liberation of parent drug was synthesized on the basis of cephalosporanate sulfone esters.