Modulation of the kynurine pathway of tryptophan metabolism in search for neuroprotective agents. Focus on kynurenine-3-hydroxylase

  • Adv Exp Med Biol. 2003;527:621-8. doi: 10.1007/978-1-4615-0135-0_71.
Roberto Pellicciari  1 ,  Laura Amori ,  Gabriele Costantino ,  Antonio Giordani ,  Antonio Macchiarulo ,  Luisa Mattoli ,  Paolo Pevarello ,  Carmela Speciale ,  Mario Varasi
Affiliations
  • 1. Dipartimento di Chimica e Tecnologia del Farmaco, Università di Perugia, Via del Liceo 1, 06123 Perugia, Italy.
PMID: 15206781 DOI: 10.1007/978-1-4615-0135-0_71
Abstract

A novel potent and selective kynurenine-3-hydroxylase inhibitor is descibed along a preliminary evaluation in a in vivo gerbil model of its ability to increase the kynurenine and kynurenic acid concentration in both plasma and brain. These data support the notion that kynurenine-3-hydroxylase inhibitors may have a sustained therapeutic potential in those diseases characterized by unbalance in the QUIN/KYNA branches of the kynurenine pathway.

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