An isocoumarin with hepatoprotective activity in Hep G2 and primary hepatocytes from Agrimonia pilosa

  • Arch Pharm Res. 2004 Sep;27(9):944-6. doi: 10.1007/BF02975848.
Eun-Jeon Park  1 ,  Hyuncheol Oh ,  Tai-Hyun Kang ,  Dong-Hwan Sohn ,  Youn-Chul Kim
Affiliations
  • 1. College of Pharmacy and Phytofermentation Research Center, Wonkwang University, Iksan 570-749, Korea.
PMID: 15473665 DOI: 10.1007/BF02975848
Abstract

Phytochemical investigation of the aqueous extract of the roots of Agrimonia pilosa Ledeb. (Rosaceae), as guided by hepatoprotective activity in vitro, furnished two isocoumarins, agrimonolide (1) and agrimonolide 6-O-beta-D-glucoside (3), and (+)-catechin (2). Compound 1 showed hepatoprotective effects on both tacrine-induced cytotoxicity in human liver-derived Hep G2 cells and tert-butyl hydroperoxide-induced cytotoxicity in rat primary hepatocytes with EC50 values of 88.2 +/- 2.8 and 37.7 +/- 1.6 microM, respectively.

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