Steroids from the roots of Cynanchum stauntonii

  • Planta Med. 2004 Nov;70(11):1075-9. doi: 10.1055/s-2004-832650.
Peng Wang  1 ,  Hai-Lin Qin ,  Ling Zhang ,  Zhi-Hong Li ,  Ying-Hong Wang ,  Hai-Bo Zhu
Affiliations
  • 1. Institute of Materia Medica, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing , P.R. China.
PMID: 15549665 DOI: 10.1055/s-2004-832650
Abstract

A chemical investigation of the roots of Cynanchum stauntonii has resulted in the characterization of a new hydroperoxide with a 13,14 : 14,15-disecopregnane-type skeleton, named stauntonine (1), together with three related compounds, anhydrohirundigenin (2), anhydrohirundigenin monothevetoside (3), and glaucogenin-C mono- D-thevetoside (4). Their structures were established by spectroscopic methods, including X-ray crystallographic diffraction analysis of stauntonine that confirmed its relative stereochemistry. The compound 1 showed dose-dependent relaxation on aortic rings with endothelium contracted by phenylepherine or KCl.

Products