A new synthetic analogue of thymidine, 7-(3-bromo-phenoxy)-thymidine, inhibits the proliferation of tumor cells

  • Bioorg Med Chem Lett. 2005 Jan 3;15(1):77-9. doi: 10.1016/j.bmcl.2004.10.039.
Kyung Noo Kim  1 ,  Jiyong Lee ,  Dong Hoon Kim ,  Jong-Shin Yoo ,  Ho Jeong Kwon
Affiliations
  • 1. Chemical Genomics National Research Laboratory, Department of Bioscience and Biotechnology, Sejong University, Seoul 143-747, Korea.
PMID: 15582414 DOI: 10.1016/j.bmcl.2004.10.039
Abstract

Modified thymidine analogues have been highlighted as useful agents for the treatment of Cancer and viral diseases due to their potent biological activities. In the present study, we synthesized a new thymidine analogue, 7-(3-bromo-phenoxy)-thymidine (4a), as a potential lead for anti-tumor agent. Compound 4a potently inhibits HeLa cell proliferation with an IC(50) of 15 microM.