3H-Quinazolin-4-ones as a new calcilytic template for the potential treatment of osteoporosis

  • Bioorg Med Chem Lett. 2005 Mar 15;15(6):1557-60. doi: 10.1016/j.bmcl.2005.01.078.
Irina Shcherbakova  1 ,  Manuel F Balandrin ,  John Fox ,  Anjan Ghatak ,  William L Heaton ,  Rebecca L Conklin
Affiliations
  • 1. Drug Discovery, NPS Pharmaceuticals, Inc., 383 Colorow Drive, Salt Lake City, UT 84108, USA. [email protected]
PMID: 15745796 DOI: 10.1016/j.bmcl.2005.01.078
Abstract

Structure-activity relationship studies, focused on identification of the active pharmacophore fragments in a single high-throughput screening calcilytic hit, resulted in the discovery of potent calcium receptor antagonists, substituted 3H-quinazolin-4-ones.