Synthesis and evaluation of 3D templates based on a taxane skeleton to circumvent P-glycoprotein-associated multidrug resistance of cancer

  • Bioorg Med Chem Lett. 2005 May 16;15(10):2601-5. doi: 10.1016/j.bmcl.2005.03.038.
Takashi Takahashi  1 ,  Kazuoki Nakai ,  Takayuki Doi ,  Masa Yasunaga ,  Hiroshi Nakagawa ,  Toshihisa Ishikawa
Affiliations
  • 1. Department of Applied Chemistry, Tokyo Institute of Technology, 2-12-1 Ookayama, Meguro, Tokyo 152-8552, Japan. [email protected]
PMID: 15863325 DOI: 10.1016/j.bmcl.2005.03.038
Abstract

We have developed a practical synthetic route to construct C-aromatic taxane derivatives as three-dimension templates by way of intramolecular alkylation. The usefulness of synthesized compounds as the core template was evaluated by using a newly developed screening system for P-glycoprotein.