Cytotoxic bisindole alkaloids from a marine sponge Spongosorites sp

  • J Nat Prod. 2005 May;68(5):711-5. doi: 10.1021/np049577a.
Baoquan Bao  1 ,  Qishi Sun ,  Xinsheng Yao ,  Jongki Hong ,  Chong-O Lee ,  Chung Ja Sim ,  Kwang Sik Im ,  Jee H Jung
Affiliations
  • 1. College of Pharmacy, Pusan National University, Busan 609-735, Korea.
PMID: 15921415 DOI: 10.1021/np049577a
Abstract

Three new bisindole Alkaloids of the hamacanthin class (1-3) and one new bisindole alkaloid of the topsentin class (6) were isolated along with known bisindole Alkaloids (4, 5, 7-11) from the MeOH extract of a marine Sponge Spongosorites sp. by bioactivity-guided fractionation. The planar structures were established on the basis of NMR, MS, and IR spectroscopic analyses. Configurations of compounds 1-4 were derived from 1H NMR data and optical rotation. Compounds 1, 4, 5, and 11 showed moderate to significant cytotoxicity against five human tumor cell lines, and compounds 1-5 showed weak Antibacterial activity against clinically isolated methicillin-resistant strains.