Globosumones A-C, cytotoxic orsellinic acid esters from the Sonoran desert endophytic fungus Chaetomium globosum

  • J Nat Prod. 2005 May;68(5):724-8. doi: 10.1021/np058014b.
Bharat P Bashyal  1 ,  E M Kithsiri Wijeratne ,  Stanley H Faeth ,  A A Leslie Gunatilaka
Affiliations
  • 1. Southwest Center for Natural Products Research and Commercialization, Office of Arid Lands Studies, College of Agriculture and Life Sciences, The University of Arizona, 250 E. Valencia Road, Tucson, Arizona 85706-6800, USA.
PMID: 15921417 DOI: 10.1021/np058014b
Abstract

Three new esters of orsellinic acid, globosumones A-C (1-3), and three known compounds, orsellinic acid (4), orcinol, and trichodion (5), were isolated from Chaetomium globosum endophytic on Ephedrafasciculata (Mormon tea). The structures of the new compounds 1-3 were established spectroscopically, which included 2D NMR experiments and 1H NMR studies on Mosher's ester derivatives. All compounds were evaluated for inhibition of cell proliferation in a panel of four Cancer cell lines, NCI-H460 (non-small cell lung Cancer), MCF-7 (breast Cancer), SF-268 (CNS glioma), and MIA Pa Ca-2 (pancreatic carcinoma), and normal human fibroblast cells (WI-38). Only globosumones A (1) and B (2) were found to be moderately active.

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