Solid-phase synthesis and anti-infective activity of a combinatorial library based on the natural product anisomycin

  • Bioorg Med Chem Lett. 2005 Sep 15;15(18):4151-4. doi: 10.1016/j.bmcl.2005.06.004.
Shuhao Shi  1 ,  Shirong Zhu ,  Samuel W Gerritz ,  Kim Esposito ,  Ramesh Padmanabha ,  Wenying Li ,  John J Herbst ,  Henry Wong ,  Yue Zhong Shu ,  Kin S Lam ,  Michael J Sofia
Affiliations
  • 1. New Leads Chemistry, 5 Research Parkway, Wallingford, CT 06492, USA. [email protected]
PMID: 16005213 DOI: 10.1016/j.bmcl.2005.06.004
Abstract

The solid-phase synthesis of a library based on the natural product anisomycin is described. The resulting library was tested against a panel of Bacterial and Fungal targets, and active compounds were identified in a Staphylococcus aureus whole-cell assay and an efflux-deficient Fungal whole-cell assay.