Flavonoids, including an unusual flavonoid-Mg2+ salt, from roots of Cudrania cochinchinensis
- Phytochemistry. 2005 Dec;66(23):2759-65. doi: 10.1016/j.phytochem.2005.09.015.
Affiliations
- 1. Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine (Ministry of Education), Beijing 100050, People's Republic of China. [email protected]
PMID: 16274710
DOI: 10.1016/j.phytochem.2005.09.015
Abstract
Four Flavonoids with 2',4'-di-oxygenated B-rings, cochinchinol A (1), cochinchinol B (2), (2R,3R)-4',7-dihydroxy-2',5-dimethoxydihydroflavonol (3), 4',7-dihydroxy-2',5-dimethoxyflavonol (4), along with 11 known compounds, were isolated from an ethanolic extract of the roots of Cudrania cochinchinensis. Their structures were elucidated by chemical and spectroscopic methods. Cochinchinol A (1) and cochinchinol B (2) have two hitherto unprecedented flavonol salt structures in natural product chemistry. Cytotoxic activities were evaluated against several different cell lines.