Design, synthesis, and evaluation of 2-alkoxydihydrocinnamates as PPAR agonists

  • Bioorg Med Chem Lett. 2006 Feb 15;16(4):915-9. doi: 10.1016/j.bmcl.2005.10.104.
Ying Lu  1 ,  Zongru Guo ,  Yanshen Guo ,  Jun Feng ,  Fengming Chu
Affiliations
  • 1. Department of Synthetic Medicinal Chemistry, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, PR China.
PMID: 16300944 DOI: 10.1016/j.bmcl.2005.10.104
Abstract

A series of 2-alkoxydihydrocinnamates were synthesized as PPARgamma and PPARalpha dual agonists. In vitro studies in cell model showed that these compounds were efficacious. Compound 1g was found to be a potent PPARalpha/gamma dual agonist and will be further evaluated for the treatment of type II diabetes.