Synthesis and biological investigation of S-aryl-S-DABO derivatives as HIV-1 inhibitors

  • Bioorg Med Chem Lett. 2006 Jul 1;16(13):3541-4. doi: 10.1016/j.bmcl.2006.03.080.
Claudia Mugnaini  1 ,  Fabrizio Manetti ,  José A Esté ,  Imma Clotet-Codina ,  Giovanni Maga ,  Reynel Cancio ,  Maurizio Botta ,  Federico Corelli
Affiliations
  • 1. Dipartimento Farmaco Chimico Tecnologico, Università degli Studi di Siena, Via De Gasperi, 2 I-53100 Siena, Italy.
PMID: 16621553 DOI: 10.1016/j.bmcl.2006.03.080
Abstract

S-Aryl-S-DABO derivatives, a novel subclass of S-DABO anti-HIV-1 agents, were synthesized via Ullmann type reaction starting from the corresponding 2-thiouracils by the aid of microwave irradiation. The results of their evaluation as inhibitors of RT are reported together with their Antiviral activity in cellular assays.