Saponins from Polygala japonica and their effects on a forced swimming test in mice

  • J Nat Prod. 2006 Apr;69(4):591-4. doi: 10.1021/np050439a.
Ting-Zhao Li  1 ,  Wei-Dong Zhang ,  Gen-Jin Yang ,  Wen-Yong Liu ,  Hai-Sheng Chen ,  Yun-Heng Shen
Affiliations
  • 1. Department of Phytochemistry, College of Pharmacy, Second Military Medical University, Shanghai 200433, People's Republic of China.
PMID: 16643032 DOI: 10.1021/np050439a
Abstract

Five new triterpenoid saponins, polygalasaponins E (1), F (2), G (3), H (4), and J (5), along with eight known ones (6-13), were isolated from the aerial parts of Polygala japonica. Their structures were established by chemical and spectroscopic means. Forced swimming tests on mice showed that saponins 1 and 4 significantly reduce the immobility status by 58.1% and 51.3% at a dosage of 100 mg/kg administrated orally once daily for 5 days, respectively.

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