Lysine sulfonamides as novel HIV-protease inhibitors: Nepsilon-acyl aromatic alpha-amino acids

  • Bioorg Med Chem Lett. 2006 Jul 1;16(13):3459-62. doi: 10.1016/j.bmcl.2006.04.011.
Brent R Stranix  1 ,  Jean-François Lavallée ,  Guy Sévigny ,  Jocelyn Yelle ,  Valérie Perron ,  Nicholas LeBerre ,  Dominik Herbart ,  Jinzi J Wu
Affiliations
  • 1. Ambrilia Biopharma Inc., 1000 chemin du Golf, Verdun, QC, Canada H3E 1H4. [email protected]
PMID: 16644213 DOI: 10.1016/j.bmcl.2006.04.011
Abstract

A series of lysine sulfonamide analogues bearing Nepsilon-acyl aromatic Amino acids were synthesized using an efficient synthetic route. Evaluation of these novel Protease Inhibitors revealed compounds with high potency against wild-type and multiple-protease inhibitor-resistant HIV viruses.