9,11-Secosterols from the soft corals Sinularia lochmodes and Sinularia leptoclados

  • J Nat Prod. 2006 May;69(5):850-2. doi: 10.1021/np060031t.
Jui-Hsin Su  1 ,  Yen-Ju Tseng ,  Hsin-Hui Huang ,  Atallah F Ahmed ,  Chung-Kuang Lu ,  Yang-Chang Wu ,  Jyh-Horng Sheu
Affiliations
  • 1. Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan, Republic of China.
PMID: 16724859 DOI: 10.1021/np060031t
Abstract

Chemical investigations on the EtOAc-soluble fractions from the EtOH extract of two Formosan soft corals afforded two new 9,11-secosteroids, 3beta,11-dihydroxy-5beta,6beta-epoxy-24-methylene-9,11-secocholestan-9-one (1) and 3beta,11-dihydroxy-24-methylene-9,11-secocholestan-9-one (2), from Sinularia lochmodes and Sinularia leptoclados, respectively, along with two known analogues (3 and 4) from S. leptoclados. The structures of the new metabolites were elucidated on the basis of extensive spectroscopic analysis and by comparison of their NMR data with those of the known compound 3. The cytotoxicity of 2-4 toward a limited panel of Cancer cell lines is also reported.