Physanolide A, a novel skeleton steroid, and other cytotoxic principles from Physalis angulata

  • Org Lett. 2006 Jul 6;8(14):2953-6. doi: 10.1021/ol060801s.
Ping-Chung Kuo  1 ,  Tsung-Hsiao Kuo ,  Amooru G Damu ,  Chung-Ren Su ,  E-Jian Lee ,  Tian-Shung Wu ,  Rexen Shu ,  Chou-Ming Chen ,  Kenneth F Bastow ,  Tzu-Hsuan Chen ,  Kuo-Hsiung Lee
Affiliations
  • 1. Department of Chemistry, National Cheng Kung University, Tainan, Taiwan, Republic of China.
PMID: 16805525 DOI: 10.1021/ol060801s
Abstract

[reaction: see text] A novel withasteroid, physanolide A (1), with an unprecedented skeleton containing a seven-membered ring, and two new physalins, physalins U (2) and V (3), were isolated from Physalis angulata. The structures were elucidated from spectroscopic analysis, and plausible biosynthetic pathways were postulated. Physalins B (4), D (5), and F (6) showed strong cytotoxicity against multiple tumor cell lines, including KB, A431, HCT-8, PC-3, and ZR751, with EC(50) values less than 4 microg/mL.

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