Radical-scavenging activities of new megastigmane glucosides from Macaranga tanarius (L.) MULL.-ARG

  • Chem Pharm Bull (Tokyo). 2006 Oct;54(10):1403-7. doi: 10.1248/cpb.54.1403.
Katsuyoshi Matsunami  1 ,  Ichiko Takamori ,  Takakazu Shinzato ,  Mitsunori Aramoto ,  Kazunari Kondo ,  Hideaki Otsuka ,  Yoshio Takeda
Affiliations
  • 1. Department of Pharmacognosy, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan.
PMID: 17015977 DOI: 10.1248/cpb.54.1403
Abstract

Four new megastigmane glucosides, named macarangiosides A-D (2-5), together with mallophenol B, lauroside E, methyl brevifolin carboxylate, and hyperin and isoquercitrin as a mixture were isolated from the leaves of Macaranga tanarius (L.) MULL.-ARG. (Euphorbiaceae). Their structures were elucidated by spectroscopic and chemical analyses. Macarangioside A-C (2-4) and mallophenol B were galloylated on glucose moiety and possessed the potent 2,2-diphenyl-picrylhydrazyl (DPPH) radical-scavenging activity.

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