[Active constituents from Aloe arborescens as BACE inhibitors]

  • Yao Xue Xue Bao. 2006 Oct;41(10):1000-3.
Bo Gao  1 ,  Chun-Suo Yao ,  Jin-Yun Zhou ,  Ruo-Yun Chen ,  Wei-Shuo Fang
Affiliations
  • 1. Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
PMID: 17184120
Abstract

Aim: To seek for new components as BACE inhibitors from Aloe arborescens.

Methods: The chemical constituents were isolated by chromatographic methods and their structures were elucidated on the basis of spectral analysis.

Results: Eight compounds were isolated and their structures identified as 6'-O-isobutyryl aloenin A (1), aloenin A (2), aloe-emodin (3), (E)-2-acetonyl-8-(2'-O-feruloxyl)-beta-D-glucopyranosyl-7-methoxy-5-methyl-chromone (4), 7-O-methylaloeresin A (5), babarloin A (6), elgonica-dimer A (7), and elgonica-dimer B (8), separately.

Conclusion: Compound 1 is a new compound, and compound 4 was isolated from A. arborescens for the first time. Pharmacological tests indicated that 2, 4, 5 and 6 have moderate inhibitory active on BACE.

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