New constituents from the leaves of Morinda citrifolia

  • Chem Pharm Bull (Tokyo). 2007 Feb;55(2):343-5. doi: 10.1248/cpb.55.343.
Junko Takashima  1 ,  Yoshitaka Ikeda ,  Kanki Komiyama ,  Masahiko Hayashi ,  Akio Kishida ,  Ayumi Ohsaki
Affiliations
  • 1. Pharmaceuticals Research Division, Mitsubishi Pharma Corporation, Yokohama, Japan. [email protected]
PMID: 17268114 DOI: 10.1248/cpb.55.343
Abstract

A new iridoid glycoside, citrifoside (1), and a new anthraquinone, 1,5,15-trimethylmorindol (2), together with 24 known compounds, were isolated from the leaves of Morinda citrifolia. The structures of the new compounds were elucidated by spectral data. 1,5,15-Trimethylmorindol (2) did not show significant cytotoxic activity by itself but showed cytotoxicity when combined with tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), while citrifoside (1) did not show any activity even with TRAIL.

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