Cytotoxic germacrane-type sesquiterpenes, pimarane-type diterpenes, and a naphthalene derivative from Wollastonia biflora

  • J Nat Prod. 2007 Apr;70(4):567-70. doi: 10.1021/np060515p.
Wenliang Chen  1 ,  Weidong Tang ,  Rujun Zhang ,  Liguang Lou ,  Weimin Zhao
Affiliations
  • 1. Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 201203, People's Republic of China.
PMID: 17291042 DOI: 10.1021/np060515p
Abstract

Phytochemical investigation of the whole Plants of Wollastonia biflora led to the isolation and identification of three new germacrane-type Sesquiterpenes (1-3), two new pimarane-type diterpenes (4, 5), and a new naphthalene glycoside (6), along with 11 known compounds. Their structures were characterized on the basis of spectroscopic analyses and chemical methods. Compounds 1, 2, and 3 showed significant cytotoxic activity against the growth of hepatocellular carcinoma BEL-7402 cells in vitro.

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