Cucurbitane glycosides from unripe fruits of Siraitia grosvenori

  • Chem Pharm Bull (Tokyo). 2007 Jul;55(7):1082-6. doi: 10.1248/cpb.55.1082.
Dianpeng Li  1 ,  Tsuyoshi Ikeda ,  Toshihiro Nohara ,  Jinlei Liu ,  Yongxin Wen ,  Tatsunori Sakamoto ,  Gen-Ichiro Nonaka
Affiliations
  • 1. Faculty of Medical and Pharmaceutical Science, Kumamoto University, Kumamoto, Japan.
PMID: 17603208 DOI: 10.1248/cpb.55.1082
Abstract

Studies on the constituents of the unripe fruits of Siraitia grosvenori led to the isolation of three new cucurbitane triterpene glycosides, 11-oxomogroside III (10), 11-dehydroxymogroside III (11), and 11-oxomogroside IV A (12). Their structures were determined on the basis of detailed analyses of 1D, 2D-NMR spectroscopic methods. All of the compounds isolated from the unripe fruits of S. grosvenori were tested for cytotoxic activities against tumor cells, HCT-116 and SMMC-7721.

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