The crystal structure and cytotoxicity of goniodiol-7-monoacetate from Goniothalamus amuyon

  • J Nat Prod. 1991 Jul-Aug;54(4):1077-81. doi: 10.1021/np50076a024.
Y C Wu  1 ,  C Y Duh ,  F R Chang ,  G Y Chang ,  S K Wang ,  J J Chang ,  D R McPhail ,  A T McPhail ,  K H Lee
Affiliations
  • 1. School of Pharmacy, Department of Microbiology, Kaohsiung Medical College, Taiwan, Republic of China.
PMID: 1791473 DOI: 10.1021/np50076a024
Abstract

The styrylpyrone, goniodiol-7-monoacetate [1] [6R-(7R,8R-dihydro-7-acetoxy-8-hydroxystyryl)-5, 6-dihydro-2-pyrone], has been isolated from Goniothalamus amuyon, and its detailed molecular structure has been determined by X-ray crystallographic analysis. Goniodiol-7-monoacetate showed potent (ED50 values less than 0.1 microgram/ml) cytotoxicities against KB, P-388, RPMI, and TE671 tumor cells.