Synthesis of amide and urea derivatives of benzothiazole as Raf-1 inhibitor

  • Eur J Med Chem. 2008 Jul;43(7):1519-24. doi: 10.1016/j.ejmech.2007.10.008.
Eun Young Song  1 ,  Navneet Kaur ,  Mi-Young Park ,  Yinglan Jin ,  Kyeong Lee ,  Guncheol Kim ,  Ki Youn Lee ,  Jee Sun Yang ,  Jae Hong Shin ,  Ky-Youb Nam ,  Kyoung Tai No ,  Gyoonhee Han
Affiliations
  • 1. Korea Research Institute of Bioscience and Biotechnology (KRIBB), Yuseong-Gu, Daejeon, Republic of Korea.
PMID: 18023932 DOI: 10.1016/j.ejmech.2007.10.008
Abstract

A series of amide and urea derivatives of benzothiazole have been synthesized and evaluated for their antiproliferative profile in human SK-Hep-1 (liver), MDA-MB-231 (breast), and NUGC-3 (gastric) cell lines. Among them, compounds 1-2, 16-18, 23, and 25-26 had potent to moderate inhibitory activities. Further these compounds were investigated for their ability to inhibit Raf-1 activity.