Synthesis and biological evaluation of diversely substituted indolin-2-ones

  • Eur J Med Chem. 2008 Nov;43(11):2316-22. doi: 10.1016/j.ejmech.2008.01.010.
Fadoua Bouchikhi  1 ,  Emilie Rossignol ,  Martine Sancelme ,  Bettina Aboab ,  Fabrice Anizon ,  Doriano Fabbro ,  Michelle Prudhomme ,  Pascale Moreau
Affiliations
  • 1. Laboratoire SEESIB, Université Blaise Pascal, UMR 6504 du CNRS, 24 avenue des Landais, F-63177 Aubière Cedex, France.
PMID: 18313174 DOI: 10.1016/j.ejmech.2008.01.010
Abstract

The synthesis of indolin-2-one derivatives substituted in the 3-position by an aminomethylene group bearing either an ornithine or a lysine residue is described. The inhibitory activities of these compounds toward a panel of eight kinases were examined. Furthermore, the Antibacterial activities of the prepared compounds were tested against two Gram-positive bacteria Bacillus cereus and Streptomyces chartreusis, a Gram-negative bacterium Escherichia coli and a yeast Candida albicans.

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