T-type Ca2+ channel blockers suppress the growth of human cancer cells

  • Bioorg Med Chem Lett. 2008 Jul 15;18(14):3899-901. doi: 10.1016/j.bmcl.2008.06.034.
Jae Ho Heo  1 ,  Han Na Seo ,  Yun Jeong Choe ,  Sujin Kim ,  Chun Rim Oh ,  Young Deuk Kim ,  Hyewhon Rhim ,  Dong Joon Choo ,  Jungahn Kim ,  Jae Yeol Lee
Affiliations
  • 1. Research Institute for Basic Sciences and Department of Chemistry, College of Sciences, Kyung Hee University, 1 Hoegi-Dong, Dongdaemun-Gu, Seoul 130-701, Republic of Korea.
PMID: 18585035 DOI: 10.1016/j.bmcl.2008.06.034
Abstract

In order to further clarify the role of T-type CA(2+) channels in cell proliferation, we have measured the growth inhibition of human Cancer cells by using our potent T-type CA(2+) channel blockers. As a result, KYS05090, a most potent T-type CA(2+) channel blocker, was found to be as potent as doxorubicin against some human Cancer cells without acute toxicity. Therefore, this letter provides the biological results that T-type calcium channel is important in regulating the important cellular phenotype transition leading to cell proliferation, and thus novel T-type CA(2+) channel blocker presents new prospects for Cancer treatment.