Comparative in vitro anti-hepatitis C virus activities of a selected series of polymerase, protease, and helicase inhibitors

  • Antimicrob Agents Chemother. 2008 Sep;52(9):3433-7. doi: 10.1128/AAC.01534-07.
Jan Paeshuyse  1 ,  Inge Vliegen ,  Lotte Coelmont ,  Pieter Leyssen ,  Oriana Tabarrini ,  Piet Herdewijn ,  Harald Mittendorfer ,  Johnny Easmon ,  Violetta Cecchetti ,  Ralf Bartenschlager ,  Gerhard Puerstinger ,  Johan Neyts
Affiliations
  • 1. Rega Institute for Medical Research, KU Leuven, Leuven, Belgium.
PMID: 18625766 DOI: 10.1128/AAC.01534-07
Abstract

We report here a comparative study of the anti-hepatitis C virus (HCV) activities of selected (i) nucleoside polymerase, (ii) nonnucleoside polymerase, (iii) alpha,gamma-diketo acid polymerase, (iv) NS3 protease, and (v) helicase inhibitors, as well as (vi) Cyclophilin binding molecules and (vii) alpha 2b interferon in four different HCV genotype 1b replicon systems.