Remarkable DNA binding affinity and potential anticancer activity of pyrrolo[2,1-c][1,4]benzodiazepine-naphthalimide conjugates linked through piperazine side-armed alkane spacers

  • Bioorg Med Chem. 2008 Aug 1;16(15):7218-24. doi: 10.1016/j.bmc.2008.06.034.
Ahmed Kamal  1 ,  R Ramu ,  Venkatesh Tekumalla ,  G B Ramesh Khanna ,  Madan S Barkume ,  Aarti S Juvekar ,  Surekha M Zingde
Affiliations
  • 1. Division of Organic Chemistry, Indian Institute of Chemical Technology, Hyderabad 500 607, India. [email protected]
PMID: 18656370 DOI: 10.1016/j.bmc.2008.06.034
Abstract

A series of pyrrolobenzodiazepine-naphthalimide conjugates tethered through a piperazine ring system have been designed, synthesized, and evaluated for their Anticancer activity. These new conjugates exhibit very high DNA binding affinity and cytotoxic activity against a number of cell lines.