Design, synthesis and nootropic activity of new analogues of sunifiram and sapunifiram, two potent cognition-enhancers

  • Bioorg Med Chem. 2009 Nov 1;17(21):7606-14. doi: 10.1016/j.bmc.2009.08.055.
Elisabetta Martini  1 ,  Alberto Salvicchi ,  Carla Ghelardini ,  Dina Manetti ,  Silvia Dei ,  Luca Guandalini ,  Cecilia Martelli ,  Michele Melchiorre ,  Cristina Cellai ,  Serena Scapecchi ,  Elisabetta Teodori ,  Maria Novella Romanelli
Affiliations
  • 1. Department of Pharmaceutical Sciences, Laboratory of Design, Synthesis and Study of Biologically Active Heterocycles (HeteroBioLab), University of Florence, 50019 Sesto Fiorentino, Italy.
PMID: 19786353 DOI: 10.1016/j.bmc.2009.08.055
Abstract

A series of amides and sulfonamides, structurally related to DM235 (sunifiram) and MN19 (sapunifiram), derived by ring expansion or contraction, or by inversion of the exocyclic amide function, have been synthesized and tested for cognition-enhancing activity in the mouse passive-avoidance test. Some of the compounds display good antiamnesic and procognitive activity, with higher potency than piracetam, and with a potency similar to the parent compounds.

Products