Cytotoxic 3,4-seco-cycloartane triterpenes from the exudate of Gardenia tubifera

  • J Nat Prod. 2010 Jan;73(1):51-4. doi: 10.1021/np900658t.
Thanesuan Nuanyai  1 ,  Sipichar Chokpaiboon ,  Tirayut Vilaivan ,  Khanitha Pudhom
Affiliations
  • 1. Research Centre of Bioorganic Chemistry, Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand.
PMID: 20028108 DOI: 10.1021/np900658t
Abstract

Four new 3,4-seco-cycloartanes, gardenoins A-D (1-4), together with the known compound secaubryenol (5), were isolated from the exudate of Gardenia tubifera. The structures of 1-4 were elucidated on the basis of spectroscopic analysis. The cytotoxic activity of compounds 1-4 was evaluated against five human tumor cell lines.