New estrogenic compounds isolated from Broussonetia kazinoki

  • Bioorg Med Chem Lett. 2010 Jun 15;20(12):3764-7. doi: 10.1016/j.bmcl.2010.04.064.
Da Yeon Lee  1 ,  Do Hee Kim ,  Hwa Jin Lee ,  YoungJoo Lee ,  Kwang Hee Ryu ,  Bo-In Jung ,  Yun Seon Song ,  Jae-Ha Ryu
Affiliations
  • 1. College of Pharmacy, Sookmyung Women's University, Seoul, Republic of Korea.
PMID: 20493686 DOI: 10.1016/j.bmcl.2010.04.064
Abstract

Two new and two known compounds were identified as estrogenic constituents from Broussonetia kazinoki. Their structures were elucidated as broussonin A (1), tupichinol C (2), kazinol U (3), and (+)-(2R) kazinol I (4). They showed estrogenic activity with ligand-binding activity of Estrogen receptor, transcriptional activity of estrogen-responsive element-luciferase reporter genes. They also control the cellular gene expression levels of estrogen-responsive genes. Phytoestrogens from B. kazinoki may have beneficial effects in the treatment of menopausal symptoms.